产品货号：
Z12725
中文名称：
Caspase 8/CASP8抗体
英文名称：
Anti-Caspase 8/CASP8 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Caspase 8/CASP8 Antibody |
| 指标别名 | Apoptotic protease Mch 5;Casp 8;CASP8;Caspase 8;Caspase 8/p18;Caspase 8/p43/p18;caspase8;FADD like ICE;FLICE;ICE like apoptotic protease 5;MCH5 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM,ELISA |
| 基因名称 | CASP8 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Caspase-8/CASP8 recombinant protein (Position:S217-D479). |
| 实际分子量 | 55KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CASP8 is also known as CAP4,MACH or MCH5.This gene encodes a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes composed of a prodomain,a large protease subunit,and a small protease subunit.Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits.This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli.The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD.In addtion,this protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls,which implicated the role in neurodegenerative diseases.Many alternatively spliced transcript variants encoding different isoforms have been described,although not all variants have had their full-length sequences determined. |
| Uniprot ID | Q14790 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | caspase 8 |
| 蛋白名全称 | Caspase-8 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 |
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